A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/519 (2006.01) A61K 31/407 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2738925
Methods for reducing or preventing the effects of cytotoxic compounds in healthy cells are provided. The methods relate to the use of selective cyclin- dependent kinase (CDK) 4/6 inhibitors to induce transient quiescence in CDK4/6 dependent cells, such as hematopoietic stem cells and/or hematopoietic progenitor cells. Also described is a method of selecting compounds for reducing or preventing the effects of cytotoxic agents compounds in healthy cells.
La présente invention concerne des méthodes permettant de réduire ou de prévenir les effets de composés cytotoxiques dans des cellules saines. Ces méthodes consistent à utiliser des inhibiteurs sélectifs des kinases dépendant des cyclines (CDK) 4/6 pour induire une quiescence transitoire dans les cellules dépendant de CDK4/6, telles que les cellules souches hématopoïétiques et/ou les cellules progénitrices hématopoïétiques. L'invention décrit également une méthode de sélection de composés permettant de réduire ou de prévenir les effets d'agents cytotoxiques dans des cellules saines.
Bisi John E.
Ramsey Matthew R.
Roberts Patrick J.
Sharpless Norman E.
Strum Jay C.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The University Of North Carolina At Chapel Hill
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