Hematopoietic stem cell expansion enhancing factor and...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/02 (2006.01) C12N 5/0789 (2010.01) A61K 35/12 (2006.01) A61K 35/28 (2006.01) A61K 38/18 (2006.01)

Patent

CA 2337574

The present invention relates to a hematopoietic stem cell expansion factor, and to a method for enhancing hematopoietic stem cell expansion by direct delivery of a protein in the cell. The method comprises directly delivering in a HSC an amino acid sequence having the activity of a peptide encoded by a Hoxb4 nucleotide sequence. Once delivered, the amino acid sequence is functionally active in the hematopoietic stem cell and enhances expansion thereof. The amino acid sequence may consist of a HOXB4 peptide.

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