Hematopoietic stem cells

Details Hematopoietic stem cells Hematopoietic stem cells

C - Chemistry, Metallurgy

12

N

C12N 5/0789 (2010.01) A61K 35/14 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2307624

The present invention relates to human hemotopoietic stem cells characterized as CD34-Lin- and CD34-CD38-Lin- and to methods of isolating and using such cells in compositions and in methods for the reconstitution of a deficient or missing cell population. The present invention also provides a population of human hematopoietic stem cells that can be isolated and genetically altered for introduction in a human patient, to correct various genetic disorders and cultured and further differentiated in vitro to provide a new population of cells.

La présente invention concerne des cellules souches hématopoïétiques humaines appelées CD34-Lin- et CD34-CD38-Lin- et des procédés d'isolement et d'utilisation de ces cellules dans des compositions et dans des méthodes de reconstitution d'une population cellulaire déficiente ou absente. La présente invention concerne également une population de cellules souches hématopoïétiques humaines pouvant être isolées et modifiées génétiquement et destinées à être introduites chez un patient humain, afin de corriger divers dysfonctionnements génétiques, mises en culture et encore différenciées in vitro pour obtenir une nouvelle population de cellules.

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