Heme-oxygenase inhibitors and use of the same in the...

Details Heme-oxygenase inhibitors and use of the same in the... Heme-oxygenase inhibitors and use of the same in the...

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) A61K 31/4164 (2006.01) A61K 31/4178 (2006.01) A61K 31/4196 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07D 233/60 (2006.01) C07D 249/08 (2006.01)

Patent

CA 2727528

Disclosed are compounds of the general formula (1): compositions comprising an effective amount of said compounds either alone or in combination with other chemotherapeutic agents, and methods useful for treating or preventing cancer and for inhibiting tumour tissue growth. These compounds attenuate the oxidative damage associated with increased heme- oxygenase activity and can reduce cell proliferation in transformed cells. In addition, the described compounds and compositions are useful as neuroprotectants and for treating or preventing neurodegenerative disorders and other diseases of the central nervous system.

L'invention porte sur des composés représentés par la formule générale (1), sur des compositions comprenant une quantité efficace desdits composés soit individuellement soit en combinaison avec d'autres agents chimiothérapeutiques, et sur des procédés utiles pour traiter ou prévenir le cancer et pour inhiber une croissance de tissu tumoral. Ces composés atténuent le dommage oxydant associé à une activité accrue de l'hème-oxygénase et permettent de réduire une prolifération cellulaire dans les cellules transformées. De plus, les composés et compositions décrits sont utiles en tant que neuroprotecteurs ainsi que pour traiter ou prévenir des troubles neurodégénératifs et autres maladies du système nerveux central.

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