Hemoglobin-antioxidant conjugates

Details Hemoglobin-antioxidant conjugates Hemoglobin-antioxidant conjugates

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2366833

There are provided biocompatible chemical compositions having oxygen transporting capability and comprising oxygen transporting molecules chemically bound to antioxidants, to form compositions capable of protecting a mammalian body from oxidative damage. An example of a composition according to the invention is hemoglobin covalently coupled to a 6-hydroxy chroman carboxylic acid, such as Trolox.

La présente invention concerne des compositions chimiques biocompatibles aptes au transport de l'oxygène et comprenant des molétules transportant l'oxygène, chimiquement liées à des antioxydants, de façon à former des compositions capables de protéger un corps de mammifère contre la dégradation oxydative. Cette composition est surtout l'hémoglobine couplée par covalence à un acide hydroxy-chroman-carboxylique tel que le Trolox.

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