Hemoglobin composition and its use

Details Hemoglobin composition and its use Hemoglobin composition and its use

C - Chemistry, Metallurgy

07

K

C07K 14/805 (2006.01) A61K 38/42 (2006.01)

Patent

CA 2060205

2060205 9013309 PCTABS00002 This invention relates to an essentially stroma-free hemoglobin composition having a desirable combination of properties for use as a universally applicable blood plasma expander etc., such as a desirable oxygen affinity value, a desirable vascular retention time and substantial absence of toxic side effects. The composition comprises human hemoglobin cross-linked intramolecularly through the .beta.-chains and polymerized. Preferably, 2-nor-2-formylpyridoxal 5-phosphate or a bis-pyridoxal polyphosphate is used for the intramolecular cross-linking through the .beta.-chains, and glutaraldehyde is used for the polymerization of the hemoglobin.

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