Hemoglobin-enzyme complexes

Details Hemoglobin-enzyme complexes Hemoglobin-enzyme complexes

C - Chemistry, Metallurgy

12

N

C12N 9/08 (2006.01) A61K 35/14 (2006.01) A61K 38/44 (2006.01) A61K 47/48 (2006.01) C07K 14/805 (2006.01) C12N 9/02 (2006.01) C12N 11/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2135739

Crosslinked hemoglobin preparations having chemically bound thereto superoxide dismutase (SOD) and catalase are provided, for use as oxygen carrying rescusitative fluids, e.g. blood substitutes. The enzymes crosslinked to the hemoglobin effectively scavenge super oxide and hydrogen peroxide to improve the performance of the fluid in respect of ischemia-reperfusion injury risks.

Préparations d'hémoglobine réticulées avec, liées chimiquement, la superoxyde-dismutase (SOD) et la catalase, pour fluides oxygénés de réanimation, comme les substituts du sang. Les enzymes réticulées avec l'hémoglobine éliminent efficacement les superoxydes et le peroxyde d'hydrogène, améliorant ainsi l'efficacité du fluide en ce qui concerne les risques d'ischémie et de lésions par reperfusion.

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