Hemoglobin-haptoglobin complexes

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01)

Patent

CA 2326720

Construct-complexes of a hemoglobin, a hepatocyte modifying substance bound to the hemoglobin, and a haptoglobin bound to the hemoglobin, are provided, for administration to mammalian patients. The construct-complex may be formed ex vivo, or a hemoglobin-hepatocyte modifying substance combination may be administered to the patient so that haptoglobin in the mammalian body bonds thereto to form the construct-complex in vivo. Disorders of the liver may be diagnosed and treated using construct-complexes described herein.

La présente invention concerne des complexes de construction d'une hémoglobine, d'une substance modificatrice d'hépatocyte lié à l'hémoglobine, et d'une haptoglobine liée à l'hémoglobine, destinés à être administrés à des mammifères. Le complexe de construction peut être formé ex vivo, ou bien formé in vivo, chez le mammifère, par liaison d'haptoglobine à une combinaison d'hémoglobine et de substance modificatrice d'hépatocyte administrée au sujet. On peut diagnostiquer et traiter des troubles du foie à l'aide des complexes de construction de la présente invention.

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