Hemoglobins as drug delivery agents

Details Hemoglobins as drug delivery agents Hemoglobins as drug delivery agents

C - Chemistry, Metallurgy

07

K

C07K 14/805 (2006.01) A61K 47/48 (2006.01) C12N 15/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2122717

The invention relates to methods and compositions for delivering drugs to the body by binding them to hemoglobin. This technique stabilizes the drug and extends its half-life in the body. The drug may be chemically coupled to or adsorbed on the hemoglobin chain(s). Polypeptide therapeutics are ideally linked to an artificial hemoglobin via a cysteine located deep within a cleft in the hemoglobin molecule.

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