C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) C12N 9/64 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2589060
The invention concerns a method for the generation of a polypeptide with specific binding properties to a predetermined target molecule which are not naturally inherent to that polypeptide. At the same time an optimization of the binding specifity and a process of production are described. The invention further concerns a method for the identification and modification of specific amino acid positions within a polypeptide scaffold.
L'invention concerne un procédé de création d'un polypeptide ayant des propriétés de liaison spécifiques avec une molécule cible prédéterminée, lesdites propriétés n'étant naturellement pas inhérentes à ce polypeptide. L'invention concerne également un procédé d'optimisation de la spécificité de liaison ainsi qu'un procédé de production. L'invention concerne également un procédé d'identification et de modification de positions spécifiques d'acides aminés dans un échafaudage polypeptidique.
Lanzendoerfer Martin
Schraeml Michael
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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