Hemophilia treatment by inhalation of coagulation factors

Details Hemophilia treatment by inhalation of coagulation factors Hemophilia treatment by inhalation of coagulation factors

A - Human Necessities

61

J

A61J 3/02 (2006.01) A61K 9/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2520970

Hemophilia treatment by the inhalation of coagulation factors. Dry powder Factor IX is aerosolized to a mass median aerodynamic diameter of 4 ~m or less, with at least 90% monomer content, at least 80% activity level, and 10% water or less. The aerosol is slowly, and deeply inhaled into the lung, and followed by a maximal exhale.

L'invention concerne un traitement de l'hémophilie par inhalation de facteurs de coagulation. Un facteur IX en poudre sèche est transformé en aérosol de diamètre aérodynamique médian de masse inférieure ou égale à 4 µm, et présente un contenu de monomère d'au moins 90 %, un niveau d'activité d'au moins 80 %, et une teneur en eau inférieure ou égale à 10 %. Cet aérosol est lentement et profondément inhalé dans le poumon, puis s'ensuit une exhalation maximale.

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