Hemostatic compositions of polyacids and polyalkylene oxides...

A - Human Necessities – 61 – L

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A61L 17/00 (2006.01) A61K 9/70 (2006.01) A61K 31/715 (2006.01) A61K 31/717 (2006.01) A61K 31/721 (2006.01) A61K 31/722 (2006.01) A61K 31/727 (2006.01) A61K 31/728 (2006.01) A61K 31/74 (2006.01) A61K 38/39 (2006.01) A61K 38/48 (2006.01) A61K 47/30 (2006.01) A61L 15/22 (2006.01) A61L 15/44 (2006.01) A61L 31/04 (2006.01) A61P 7/04 (2006.01) C08L 71/02 (2006.01) A61K 38/00 (2006.01) C08L 67/00 (2006.01) C08L 77/00 (2006.01) C08L 85/00 (2006.01) C08L 85/02 (2006.01)

Patent

CA 2407235

The present invention relates to improved methods for making and using hemostatic, bioadhesive, bioresorbable, anti-adhesion compositions made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyether, polyacids, polyalkylene oxides, and optionally including multivalent cations and/or polycations and/or hemostatic agents. The polymers can be associated with each other, and are then either dried into membranes or sponges, or are used as fluids, gels, or foams. Hemostatic, bioresorbable, bioadhesive, anti-adhesion compositions are useful in surgery to prevent bleeding and the formation and reformation of post-surgical adhesions. The compositions are designed to breakdown in-vivo, and thus be removed from the body. The hemostatic, anti-adhesion, bioadhesive, bioresorptive, antithrombogenic and/or physical properties of such compositions can be varied as needed by carefully adjusting the pH, solids content cation content of the polymer casting solutions, polyacid composition, the polyalkylene oxide composition, or by adding hemostatic agents. Hemostatic membranes, gels and/or foams can be used concurrently. Hemostatic, antiadhesion compositions may also be used to lubricate tissues and/or medical instruments, and/or deliver drugs to the surgical site and release them locally.

L'invention concerne des procédés améliorés destinés à fabriquer et à utiliser des compositions hémostatiques, bioadhésives, biorésorbables et anti-adhésives constituées de complexes intermacromoléculaires de polysaccharides à teneur en carboxyle, de polyéthers, de polyacides, d'oxydes polyalkylène et contenant éventuellement des cations multivalents et/ou des polycations et/ou des agents hémostatiques. Les polymères peuvent être associés les uns aux autres, et sont ensuite soit séchés en membranes ou en éponges soit utilisées comme fluides, gels ou mousses. Les compositions hémostatiques, bioadhésives, biorésorbables et anti-adhésives sont utiles en chirurgie dans la prévention d'hémorragies et la formation ou la reformation d'adhésions post-chirurgicales. Les compositions sont conçues pour se décomposer in-vivo, et être ainsi éliminées du corps. Les propriétés hémostatiques, anti-adhésives, bioadhésives, biorésorbables, antithrombogènes et/ou physiques de ces compositions peuvent être modifiées selon les besoins par un ajustement précis du pH, des cations à contenu solide présents dans les solutions de moulage polymères, de la composition polyacide, de la composition d'oxyde polyalkylène, ou par addition d'agents hémostatiques. Les membranes, les gels et/ou les mousses hémostatiques peuvent être utilisés conjointement. Les compositions hémostatiques et anti-adhésives peuvent aussi être utilisées pour lubrifier des tissus et/ou des instruments médicaux, et/ou administrer des médicaments au site chirurgical et les libérer localement.

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