Hemostatic microspheres

Details Hemostatic microspheres Hemostatic microspheres

A - Human Necessities

61

K

A61K 38/39 (2006.01) A61K 9/14 (2006.01) A61K 38/48 (2006.01) A61L 26/00 (2006.01) A61P 7/04 (2006.01) C12N 11/02 (2006.01) C12N 9/74 (2006.01)

Patent

CA 2716010

Provided herein are hemostatic compositions. In one embodiment, the hemostatic composition includes cross-linked polymer microspheres, such as cross-linked gelatin microspheres with pores. In another embodiment, the hemostatic composition comprises an additive such as a wetting agent, a suspending agent, or both. The hemostatic compositions may also include a hemostatic agent such as thrombin, and may include a high concentration of thrombin. The hemostatic compositions may also include plasma. Also provided herein are devices for dispersing said hemostatic compositions in a diluent, and delivering said dispersed hemostatic composition. The hemostatic compositions may also fabricated with a selected geometry as administration suggests.

L'invention concerne des compositions hémostatiques. Dans un mode de réalisation, les compositions hémostatiques incluent des microsphères de polymère réticulé, telles que des microsphères de gélatine réticulée avec pores. Dans un autre mode de réalisation, la composition hémostatique comporte un additif tel qu'un agent mouillant, un agent de mise en suspension ou ces deux agents. Les compositions hémostatiques peuvent aussi inclure un agent hémostatique tel que la thrombine et peuvent inclure une forte concentration de thrombine. Les compositions hémostatiques peuvent également inclure du plasma. L'invention concerne aussi des dispositifs permettant de disperser lesdites compositions hémostatiques dans un diluant et d'administrer ladite composition hémostatique dispersée. Les compositions hémostatiques peuvent également être fabriquées avec une géométrie sélectionnée en fonction des besoins d'administration.

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