C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/16 (2006.01) C07K 14/745 (2006.01) C07K 14/755 (2006.01)
Patent
CA 2406626
The invention relates to a method for producing a haemostatically active preparation, which contains von Willebrand factors (vWF), from a fraction of human plasmas by chromatographically purifying a plasma fraction containing vWF on an anion exchanger material that comprises the anion exchanger groups on graft polymeric structures (tentacle materials), by collecting a fraction containing vWF, followed by a purification of this fraction by means of gel permeation in order to produce a purified thermostable preparation containing vWF, and by heating the preparation in order to inactivate viruses.
Procédé de production d'une préparation contenant du facteur de von Willebrand (vWF) à action hémostatique à partir d'une fraction de plasma humain qui consiste à purifier par chromatographie une fraction de plasma contenant du vWF sur une matière échangeuse d'anions qui possède des groupes échangeurs d'anions sur des structures polymères greffées (matière tentaculaire), à recueillir une fraction contenant du vWF, puis à purifier ladite fraction à l'aide d'une filtration sur gel pour produire une préparation purifiée stable à la chaleur contenant du vWF, et enfin à chauffer ladite préparation pour inactiver les virus.
Gruber Gerhard
Josic Djuro
Stadler Monika
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Octapharma Ag
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