Heparan sulfate synthesis

Details Heparan sulfate synthesis Heparan sulfate synthesis

C - Chemistry, Metallurgy

07

H

C07H 3/04 (2006.01) C07H 5/04 (2006.01) C07H 15/04 (2006.01)

Patent

CA 2757091

The invention provides an efficient modular chemical synthesis for heparan sulfate oligosaccharides based on orthogonal protection strategies. Modular disaccharide building blocks, themselves the product of a novel combinatorial synthesis, are combined in numerous ways to produce a range of oligosaccharides.

La présente invention concerne un procédé efficace et modulaire de synthèse chimique d'oligosaccharides de type sulfate d'héparane, procédé fondé sur des stratégies de protection orthogonale. Des éléments constitutifs modulaires disaccharidiques, qui sont eux-mêmes le produit d'un procédé inédit de synthèse combinatoire, sont combinés entre eux de diverses manières pour produire un large choix d'oligosaccharides.

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