A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61P 31/04 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2188395
Pharmaceutical composition for the prevention or treatment of diseases or conditions associated with induction of the cytokine cascade by lipopolysaccharide (LPS), the composition comprising a heparin-binding protein (HBP) which, in glycosylated form, has an apparent molecular weight of 28 kD (as determined by SDS-PAGE under reducing conditions), the protein being produced in the azurophil granules of polumorphonuclear leukocytes, together with a pharmaceutically acceptable carrier or diluent. The heparin-binding protein is produced in host cells containing a DNA sequence encoding N-terminally extended HBP or encoding HBP preceded by and fused to a DNA sequence encoding another protein. Also disclosed is a process wherein the culture medium contains a sulphated polysaccharide.
Composition pharmaceutique destinée à la prévention ou au traitement de pathologies ou états associés à l'induction de la réaction en cascade de cytokine par lipopolysaccharide (LPS), cette composition comprenant une protéine de liaison de l'héparine (HPB) qui, sous une forme glycosylée, présente un poids moléculaire apparent de 28kD (tel que déterminé par électrophorèse sur gel SDS-PAGE dans des conditions réductrices), et qui est produite dans les granules azurophiles des leucocytes polymorphonucléaires, la composition comprenant également un excipient ou un diluant pharmaceutiquement acceptable.
Flodgaard Hans Jakob Hem
Rasmussen Poul Baad
Leukotech A/s
Mccarthy Tetrault Llp
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