Heparin compositions and selectin inhibition

Details Heparin compositions and selectin inhibition Heparin compositions and selectin inhibition

A - Human Necessities

61

K

A61K 31/727 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2616166

The disclosure provides in vitro and in vivo methods for identifying Heparins and Heparinoids that modulate the activity of selectins . The disclosure also provides Heparins and Heparinoids that modulate the activity of selectins . The identification and isolation of these heparin formulations has the potential to mediate a wide variety of pathologies mediated by P- and/or L- selectin, including hematogenous metastasis, diseases associated with inflammation (e.g., asthma, arthritis, allergic dermatitis), ischemia- reperfusion injury, or other pathologies such as sickle cell anemia. Selectin inhibition can be achieved at plasma concentrations lower than those that cause excessive anticoagulation or unwanted bleeding in a human subject.

L'invention porte sur des méthodes in vitro et in vivo d'identification d'héparines et d'héparinoïdes modulant l'activité des sélectines et sur ces d'héparines et d'héparinoïdes. L'identification et l'isolement de ces préparations d'héparine permet de traiter une grande variété de pathologies médiées par la P-sélectine et/ou la L-sélectine dont les métastases hématogènes, les maladies associées à l'inflammation(par exemple l'asthme, l'arthrite, les dermatites allergiques), les lésions par reperfusion d'ischémies ou d'autres pathologies telle que l'anémie falciforme. L'inhibition de la sélectine peut de faire pour des concentrations plasmatiques inférieures à celles qui entraînent une anticoagulation excessive ou des saignements indésirés chez l'homme.

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