C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/10 (2006.01) A61K 31/727 (2006.01) A61K 45/06 (2006.01) C08B 37/00 (2006.01)
Patent
CA 2377734
The present invention provides compositions and methods for the treatment of cardiovascular diseases. More particularly, the present invention relates to modifying thrombus formation by administering an agent which, <i>inter alia</i>, is capable of (1) inactivating fluid-phase thrombin and thrombin which is bound either to fibrin in a clot or to some other surface by catalyzing antithrombin; and (2) inhibiting thrombin generation by catalyzing factor Xa inactivation by antithrombin III (ATIII). The compositions and methods of the present invention are particularly useful for preventing thrombosis in the circuit of cardiac bypass apparatus and in patients undergoing renal dialysis, and for treating patients suffering from or at risk of suffering from thrombus-related cardiovascular conditions, such as unstable angina, acute myocardial infarction (heart attack), cerebrovascular accidents (stroke), pulmonary embolism, deep vein thrombosis, arterial thrombosis, etc.
La présente invention concerne des compositions et des méthodes de traitement de maladies cardio-vasculaires. Plus particulièrement, l'invention a trait à la modification de la formation de thrombus par l'administration d'un agent qui, <i>entre autres</i>, est capable: (1) d'inactiver la thrombine en phase fluide et la thrombine liée à la fibrine d'un caillot ou à une autre surface par catalyse d'antithrombine; et (2) d'inhiber la production de thrombine en catalysant l'inactivation du facteur Xa par l'antithrombine III (ATIII). Les compositions et les procédés de l'invention sont particulièrement utiles pour prévenir une thrombose dans le circuit d'un dispositif de pontage cardiaque et chez des patients subissant une dialyse rénale, et pour des traiter des patients souffrant d'affections cardio-vasculaires liées au thrombus ou à risque pour de telles affections, telles que l'angor instable, l'infarctus aigu du myocarde (crise cardiaque), les accidents vasculaires cérébraux (attaque cérébrale), l'embolie pulmonaire, la thrombose veineuse profonde, la thrombose artérielle, etc.
Hirsh Jack
Weitz Jeffrey I.
Hamilton Civic Hospitals Research Development Inc.
Mccarthy Tetrault Llp
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