Heparin derivatives and low molecular weight heparin...

Details Heparin derivatives and low molecular weight heparin... Heparin derivatives and low molecular weight heparin...

C - Chemistry, Metallurgy

08

B

167/199, 260/226

C08B 37/10 (2006.01) C08B 37/00 (2006.01)

Patent

CA 1312861

ABSTRACT HEPARIN DERIVATIVES The present invention is directed to a number of different derivatives of heparin and low molecular weight heparin. These include acetyl ester derivatives of heparin and ester derivatives of low molecular weight heparin which exhibit improved anti-Xa activity in relation to global anticlotting activity. Also disclosed are ester derivatives of heparin exhibiting low anti-Xa activity in relation to global anticlotting activity. Further disclosed are heparin derivatives and low molecular weight heparin derivatives containing hydrophobic groups and exhibiting improved permeability and which further exhibit anticoagulant activity and improved solubility in organic solvents.

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