Heparin derivatives and process for their preparation

Details Heparin derivatives and process for their preparation Heparin derivatives and process for their preparation

C - Chemistry, Metallurgy

08

B

260/226

C08B 37/10 (2006.01) C08B 37/00 (2006.01)

Patent

CA 1309402

ABSTRACT New heparin derivative having antithrombotic activity, also endowed with reduced hemorrhagic and anticoagulant effects, obtained by treating in a basic medium heparins of various origin, optionally in the presence of alkali metal salts and of a reducing agent. The heparin derivatives obtained through this treat- ment show peculiar chemico-physical characteristics, like new signals at about 53 and 54 p.p.m. in the 13C-NMR spectrum and a raise of the specific rotatory power, compared to that of the starting heparins, to values between +50° to +90°. Said structural modifications produce an improvement of the biological properties of the heparin, substantially keeping the antithrombotic activity while diminishing the hemorrhagic effect in vivo and the anticoagulant activity in vitro.

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