C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/60 (2006.01) A61K 31/715 (2006.01) A61K 31/726 (2006.01) A61K 38/51 (2006.01) C08B 37/00 (2006.01) C12N 9/88 (2006.01) C12P 19/26 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2402160
The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
La présente invention concerne l'héparinase III et des mutants de cette enzyme. L'invention porte sur la découverte de formes modifiées d'héparinase III à activité enzymatique réduite qui sont utiles à divers égards, notamment pour le séquençage de glycosaminoglycanes de type héparine (HLGAG), l'extraction de sulfate d'héparane d'une solution, l'inhibition de l'angiogenèse, notamment. D'autres aspects de l'invention concerne des méthodes de traitement du cancer et l'inhibition de la croissance de cellules tumorales et/ou de métastases au moyen de l'héparinase III ainsi que des produits obtenus par clivage enzymatique au moyen de l'héparinase III de HLGAG.
Dongfang Liu
El-Shabrawi Yosuf
Holley Kristine
Pojasek Kevin
Sasisekharan Ram
Massachusetts Institute Of Technology
Smart & Biggar
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