Hepatic growth factor receptor is the met proto-oncogene

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/12 (2006.01) A61K 38/19 (2006.01) C07K 14/475 (2006.01) C07K 14/71 (2006.01) C07K 16/22 (2006.01) C07K 16/28 (2006.01) C07K 16/32 (2006.01) C07K 16/40 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2099865

The present invention relates to a complex comprising hepatocyte growth factor (HGF) and met proto-oncogene protein. The present invention also relates to methods for detecting the presence of HGF ligand, met proto-oncogene receptor and methods for isolating either the ligand or receptor or complex comprising both. The present invention further relates to methods of diagnostic proliferative disorders and diseases such as hepatitis or hepatocarcinogenesis by detecting these ligand-receptor pairs.

Complexe renfermant un HGF (facteur de croissance des hépatocytes) et une protéine de proto-oncogène de type met. L'invention porte également sur les méthodes pour déceler la présence de ligand de HGF, de récepteur de proto-oncogène de type met, ainsi que sur les méthodes pour isoler soit le ligand, soit le récepteur, soit un complexe renfermant les deux. Enfin, l'invention présente des méthodes de diagnostic de troubles et d'affections de type prolifératif, comme l'hépatite ou les cancers hépatiques, grâce à la détection de ces paires ligand-récepteur.

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