C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/077 (2010.01) C12N 5/071 (2010.01) G01N 33/569 (2006.01) A61K 35/407 (2006.01)
Patent
CA 2688309
The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic profile of the precursors is MHC class Ia negative, ICAM-I+, VCAM-I+, .beta.3-integrin+. In addition to expression of these surface markers, the cells also express the intracellular markers desmin, vimentin, smooth muscle .alpha.-actin, nestin, hepatocyte growth factor, stromal derived factor- l.alpha. and Hlx homeobox transcriptional factor.
L'invention concerne des cellules précurseurs de cellules étoilées du foie, des compositions contenant ces cellules précurseurs et des procédés d'isolement de celles-ci. Le profil antigénique de surface des précurseurs est de classe Ia négatif du complexe majeur d'histocompatibilité (MHC), ICAM-I+, VCAM-I+, .beta.3-intégrine+. En plus de l'expression de ces marqueurs de surface, les cellules expriment également les marqueurs intracellulaires desmine, vimentine, .alpha.-actine de muscle lisse, nestine, facteur de croissance d'hépatocyte, facteur l.alpha. stromal et facteur de transcription de boîte homéotique Hlx.
Kubota Hiroshi
Reid Lola M.
Gowling Lafleur Henderson Llp
University Of North Carolina At Chapel Hill
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