Hepatitis a vaccines

Details Hepatitis a vaccines Hepatitis a vaccines

C - Chemistry, Metallurgy

12

N

C12N 15/51 (2006.01) A61K 39/29 (2006.01) C07K 14/10 (2006.01) C12N 7/01 (2006.01) C12N 15/86 (2006.01) C12N 15/863 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2072982

An isolated polypeptide comprising a substantially antigenic part of at least one hepatitis A virus epitope, the polypeptide being free from infectious material. The polypeptide is the expression product of a DNA molecule which has been incorporated into a virus, preferably vaccinia virus, using recombinant DNA technology. This expression product, of the recombinant virus containing the DNA molecule coding for it, may be incorporated into a vaccine for immunising against hepatitis A virus.

Polypeptide isolé comprenant une partie pratiquement antigénique d'au moins un épitope du virus de l'hépatite A, le polypeptide étant exempt de matière infectieuse. Le polypeptide est le produit d'expression d'une molécule d'ADN qui a été introduite dans un virus, préférablement le virus de la vaccine, à l'aide d'une technique de recombinaison de l'ADN. Ce produit d'expression, du virus de recombinaison contenant la molécule d'ADN codant pour lui, peut être introduit dans un vaccin pour immuniser le porteur contre le virus de l'hépatite A.

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