Hepatitis a vaccines

Details Hepatitis a vaccines Hepatitis a vaccines

C - Chemistry, Metallurgy

12

N

C12N 7/00 (2006.01) A61K 39/29 (2006.01) A61K 39/295 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2347084

A process for the production of inactivated Hepatitis A virus substantially free of host cell contamination is described, the process comprising: a) culturing Hepatitis A virus and harvesting a hepatitis A preparation; b) treating said hepatitis A preparation with a protease; and thereafter c) separating intact virus from protease-digested material; d) inactivating said virus. Also described are vaccines comprising the inactivated hepatitis A virus, preferably in combination with strong adjuvants.

Ce procédé de production de virus inactivé de l'hépatite A, sensiblement exempt de contamination par des cellules hôtes, consiste, (a), à cultiver le virus de l'hépatite A et à recueillir une préparation de celui-ci, (b), à traiter cette préparation à l'aide d'une protéase, puis, (c), à séparer le virus intact du matériau digéré par la protéase et, (d), à inactiver le virus. Cette invention a également trait au virus inactivé de l'hépatite A, de préférence en association avec des produits d'addition forts.

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