Hepatitis a virus cell culture in vitro

Details Hepatitis a virus cell culture in vitro Hepatitis a virus cell culture in vitro

A - Human Necessities

61

K

167/130

A61K 39/29 (2006.01)

Patent

CA 1135621

16216 HEPATITIS A VIRUS CELL CULTURE IN VITRO ABSTRACT OF THE DISCLOSURE Hepatitis A virus is passaged at least once in a susceptible sub-human primate; the infected liver from such passage is used to inoculate an in vitro cell culture, the inoculated cell culture is incubated until hepatitis A antigen is detected in the cell sheet or culture fluid, and at least two serial in vitro passages in cell culture are carried out. The hepatitis A virus so modified can be used to prepare live, attenuated hepatitis A vaccine or an inactivated hepatitis A vaccine.

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