Hepatitis a virus vaccine

Details Hepatitis a virus vaccine Hepatitis a virus vaccine

C - Chemistry, Metallurgy

12

N

C12N 7/00 (2006.01) A61K 39/29 (2006.01)

Patent

CA 2103515

TITLE OF THE INVENTION HEPATITIS A VIRUS VACCINE ABSTRACT OF THE INVENTION A complete, commercial scale highly reproducible process for producing stable hepatitis A virus (HAV) comprises optimized growth, harvest, and antigen purification conditions, to yield a >95% pure HAV on the basis of protein. Further processing steps yield an inactivated HAV vaccine formulation which is immunogenic, well tolerated, and efficacious in protection against infection by virulent HAV. The product content of protein, carbohydrate, lipid, DNA and RNA is characterized.

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