Hepatitis a virus vaccines

Details Hepatitis a virus vaccines Hepatitis a virus vaccines

C - Chemistry, Metallurgy

12

N

530/13, 167/130,

C12N 15/51 (2006.01) A61K 39/29 (2006.01) A61K 39/385 (2006.01) C07H 21/00 (2006.01) C07K 7/08 (2006.01) C07K 14/10 (2006.01) C07K 17/02 (2006.01) C12N 9/02 (2006.01) C12N 15/81 (2006.01) C12N 15/86 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1324094

HEPATITIS A VIRUS VACCINES Abstract The complete genome of the hepatitis A virus (HAV) is disclosed. With the entire genomic sequence available, epitopes are identified by analogy to known picornaviruses such as polio virus, synthesized chemically, and conjugated to carrier proteins to provide protective vaccines against HAV. Alternate methods of preparing vaccines include preparation of specified peptide sequences using recombinant techniques, preparation of deleted virions by modifying the genome to destroy the replicase and LTR regions, and preparation of particulate immunogenic materials containing an epitope from HAV. The foregoing alternatives for vaccine preparation are described, and proteins thus prepared used to raise antibodies against HAV.

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