Hepatitis b escape mutant specific binding molecules

Details Hepatitis b escape mutant specific binding molecules Hepatitis b escape mutant specific binding molecules

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 39/42 (2006.01) A61K 49/00 (2006.01) C07K 16/08 (2006.01) C07K 16/46 (2006.01) G01N 33/576 (2006.01)

Patent

CA 2158866

Molecules which are capable of specifically binding to a hepatitis B escape mutant antigenic determinant include monoclonal antibodies secreted by the cell line SMH HBs 145/G/R/I (ECACC 92122312), SMH HBs 145/R/I (ECACC 93052626), SMH HBs 145/G/R/II (ECACC 93033109) or SMH HBs 145/R/II (ECACC 93033110) and other specific binding molecules cross-competitive with them. Antibodies secreted by the cell lines SMH HBs 145/G/R/I and SMH HBs 145/G/R/II bind variant (escape mutant) HBsAG and wild type HBsAG. Antibodies secreted by the cell lines SMH HBs 145/R/I and SMH HBs 145/R/II bind variant but not wild type.

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