Hepatitis b vaccine

Details Hepatitis b vaccine Hepatitis b vaccine

C - Chemistry, Metallurgy

12

N

C12N 15/36 (2006.01) A61K 39/29 (2006.01) A61K 39/395 (2006.01) A61P 31/12 (2006.01) A61P 31/20 (2006.01) C07K 14/02 (2006.01) C07K 16/08 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01) G01N 33/576 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2182375

A variant and so-called "escape mutant" HBsAg protein or fragment thereof displaying the antigenicity of hepatitis B virus surface antigen is disclosed, in which the mutant protein or fragment thereof (mHBsAg) comprises a modified 'a' determinant in which at least two amino acids are inserted downstream of position (122) of the wild type HBsAg sequence. A vaccine comprising the mHBsAg is provided, as is a kit for diagnostic in vitro detection of anti-mHBsAg antibodies and an antibody preparation comprising anti-mHBsAg antibodies.

Protéine HBsAg variante ou dite "mutante à perte de fonction immunitaire" ou fragment de ladite protéine présentant l'antigénicité de l'antigène de surface du virus de l'hépatite B. La protéine mutante ou le fragment de ladite protéine (mHBsAg) comprend un déterminant 'a' modifié dans lequel au moins deux acides aminés sont insérés en aval de la position (122) de la séquence HBsAg de type sauvage. Un vaccin comprenant le mHBsAg est décrit, ainsi qu'un nécessaire de détection diagnostique in vitro d'anticorps anti-mHBsAg et une préparation contenant des anticorps anti-mHBsAg.

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