Hepatitis b vaccine formulation incorporating a bile acid salt

Details Hepatitis b vaccine formulation incorporating a bile acid salt Hepatitis b vaccine formulation incorporating a bile acid salt

C - Chemistry, Metallurgy

12

N

C12N 15/51 (2006.01) A61K 39/29 (2006.01) A61K 39/39 (2006.01) C07K 1/36 (2006.01) C07K 14/02 (2006.01) C12N 1/19 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2096650

2096650 9305811 PCTABS00021 A novel, highly immunogenic hepatitis B vaccine formulation comprising HBsAg produced as the result of recombinant yeast host cell expression and a bile salt, particularly sodium deoxycholate, are disclosed, as are the methods used to produce the vaccine. These methods include novel yeast culture conditions and novel HBsAg purification and adjuvanting protocols. In addition, methods utilizing these novel HBsAg formulations to immunize mammals, particularly humans, susceptible to hepatitis B infection are also described.

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