Hepatitis b virus surface antigen as a mucosal...

A - Human Necessities – 61 – K

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Details

A61K 39/39 (2006.01) A61K 39/29 (2006.01)

Patent

CA 2471727

The invention relates to a musocal surface antigen which is used to promote an increase in the immune response against co-administered antigens in the formulations outlined in the invention. Said novel formulations are obtained from the dual use of the surface antigen as an immunostimulatory agent and, at the same time, as a vaccine antigen. In this way, it is possible to obtain multiple formulations of the hepatitis B surface antigen and heterologous antigens, with immunogenicity levels similar to those obtained following parenteral administration and with a reduction in components that can dispense with the use of nasal adjuvants, thereby converting said antigens into elements that can promote an increase in the response to other co-administered antigens. Said novel use of the hepatitis B virus surface antigen and the resulting antigen formulations can be used in the pharmaceutical industry as therapeutic and preventive vaccine formulations.

L'invention concerne un antigène de surface par voie des muqueuses servant à favoriser une augmentation de la réponse immunitaire contre les antigènes co-administrés dans les formulations décrites dans cette invention. Ces nouvelles formulations sont obtenues à partir de la double utilisation de l'antigène de surface comme agent immunostimulateur et à la fois comme agent antigène vaccinal. Ainsi, il est possible d'obtenir des formulations multiples de l'antigène de surface de l'hépatite B et des antigène hétérologues, avec des niveaux d'immunogénicité semblables à ceux obtenus après administration parentérale et avec une économie de composants capable de rendre inutile l'utilisation d'adjuvants nasaux, ce qui fait des antigènes des éléments capables de favoriser la croissance de la réponse immunitaire face à d'autres antigènes co-administrés. Cette nouvelle utilisation de l'antigène de surface du virus de l'hépatite B et les formulations antigéniques obtenues trouvent une application dans l'industrie pharmaceutique sous forme de formulations vaccinales préventives ou thérapeutiques.

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