Hepatitis b virus surface proteins with reduced host...

Details Hepatitis b virus surface proteins with reduced host... Hepatitis b virus surface proteins with reduced host...

C - Chemistry, Metallurgy

12

N

C12N 15/81 (2006.01) A61K 39/29 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/02 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2067290

41/JWW23 18346 TITLE OF THE INVENTION HEPATITIS B VIRUS SURFACE PROTEINS WITH REDUCED HOST CARBOUYDRATE CONTENT ABSTRACT OF THE INVENTION In order to produce hepatitis B virus (HBV) surface proteins in the form of particles with substantially reduced entrapped carbohydrate content, DNA encoding the B V surface proteins was expressed in a recombinant yeast host which is deficient in its ability to glycosylate proteins. These BBV surface proteins display the antigenic sites genetically encoded by the S domain of the HBV virion envelope open reading frame and contains substantially reduced levels of entrapped carbohydrate when compared with HBsAg particles produced in "wild-type" yeast cells. These particles are useful as a vaccine for both the active and passive treatment or prevention of disease and/or infection caused by HBV or other agents serologically related to HBV.

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