Hepatitis c antibodies and uses thereof

Details Hepatitis c antibodies and uses thereof Hepatitis c antibodies and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/10 (2006.01) A61K 39/42 (2006.01) C12N 5/10 (2006.01) C07K 14/18 (2006.01)

Patent

CA 2738644

The present invention provides identification and characterization of conformational epitopes of the envelope pro-tein E2 of the Hepatitis C virus (HCV). The present invention provides a panel of human monoclonal antibodies that recognize conformational epitopes of E2. The antibodies are derived from patients infected with HCV. The present invention provides meth-ods for utilizing HCV antibodies as therapeutic, diagnostic, and/or prophylactic agents. The present invention provides mimotopes with conformational epitopes intact and methods of using mimotopes. The present invention provides methods of stratifying pa-tients based on their response to HCV. The present invention provides pharmaceutical compositions for prevention and treatment of HCV comprising one or more HCV antibodies.

La présente invention concerne lidentification et la caractérisation dépitopes conformationnels de la protéine denveloppe E2 du virus de lhépatite C (VHC). La présente invention concerne un panel danticorps monoclonaux humains qui reconnaissent des épitopes conformationnels dE2. Les anticorps sont dérivés de patients infectés avec le VHC. La présente invention concerne des méthodes dutilisation des anticorps anti-VHC en tant quagents thérapeutiques, diagnostiques et/ou prophylactiques. La présente invention concerne des mimotopes comportant des épitopes conformationnels intacts et des méthodes dutilisation des mimotopes. La présente invention concerne des méthodes de stratification de patients en fonction de leur réponse au VHC. La présente invention concerne des compositions pharmaceutiques destinées à la prévention et au traitement du VHC, qui comprennent un ou plusieurs anticorps anti-VHC.

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