Hepatitis c assay utilizing recombinant antigens from ns5...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/18 (2006.01) G01N 33/576 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2115925

2115925 9304089 PCTABS00020 The present invention provides a unique recombinant antigen representing the distinct NS5 antigenic region of the HCV genome which can be used as reagents for the detection of antibodies and antigen in body fluids from individuals exposed to hepatitis C virus (HCV). The present invention also provides an assay for detecting the presence of an antibody to an HCV antigen in a sample by contacting the sample with the recombinant antigen. Preferred assay formats include a screening assay, a confirmatory assay, a competition or neutralization assay and an immunodot assay.

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