Hepatitis c inhibitor compounds

Details Hepatitis c inhibitor compounds Hepatitis c inhibitor compounds

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/4709 (2006.01) A61K 31/506 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2737958

Compounds of Formula (I): wherein B, R3, L0, L1, R2, R c and R1 are defined herein. The compounds are useful as inhibitors of HCV NS3 protease for the treatment of hepatitis C viral infection. In particular, the present invention provides novel peptide analogs, pharmaceutical compositions containing such analogs, and uses of these analogs in the treatment of HCV infection

L'invention porte sur des composés représentés par la formule (I) : dans laquelle B, R3, L0, L1, R2, Rc et R1 sont tels que définis dans la description. Les composés sont utiles comme inhibiteurs de la protéase NS3 du VHC pour le traitement d'une infection virale de type hépatite C. En particulier, la présente invention porte sur de nouveaux analogues peptidiques, sur des compositions pharmaceutiques contenant de tels analogues et sur des utilisations de ces analogues dans le traitement d'une infection à VHC.

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