Hepatitis c inhibitor peptide analogs with a quinoline or a...

C - Chemistry – Metallurgy – 07 – D

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C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61K 31/4709 (2006.01) A61P 31/12 (2006.01) C07D 215/22 (2006.01) C07D 401/12 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2615921

Compounds of formula I: (see formula I) wherein R1, R2, R3, R4 and R5 are defined herein, are useful as inhibitors of the HCV NS3 protease. The invention further relates to azalactone compounds of the formula (II) which can be reacted with an amide anion to produce the HCV NS3 protease inhibitors of formula (I).

L'invention porte sur des composés de la formule (1) dans laquelle R1, R2, R3, R4 and R5 sont tels que définis dans la description, qui sont utilisés comme inhibiteurs de la protéase NS3 du virus de l'hépatite C. L'invention concerne également des composés azalactone de la formule (2) qui peuvent être mis à réagir avec un anion amide afin de produire les inhibiteurs de la protéase NS3 du VHC de la formule (1).

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