Hepatitis c inhibitor tri-peptides

Details Hepatitis c inhibitor tri-peptides Hepatitis c inhibitor tri-peptides

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/4709 (2006.01) A61P 31/12 (2006.01) C07K 5/08 (2006.01) C07K 5/083 (2006.01) C07K 5/087 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2369970

27 Racemates, diastereoisomers and optical isomers of a compound of formula (I): Image wherein B is H, a C, ar C10 aryl, C7-16 aralkyl; Het or (lower alkyl)-Het, all of which optionally substituted with C1-6 alkyl; C1-6 alkoxy; C1-6 alkanoyl; hydroxy; hydroxyalkyl; halo; haloalkyl; nitro; cyano; cyanoalkyl; amino optionally substituted with C1-6 alkyl; amido; or (lower alkyl)amide; or B is an acyl derivative of formula R4-C(O)-; a carboxyl of formula R4-O-C(O)-; an amide of formula R4-N(R6)-C(O)-; a thioamide of formula R4-N(R5)-C(S)-:or a sulfonyl of formula R4-SO2; R5 is H or C1-6 alkyl; and Y is H or C1-6 alkyl; R3 is C1-6 alkyl, C3-7 cycloalkyl, or C4-10 alkylcycloalkyl, all optionally substituted with hydroxy, C1-6 alkoxy, C1-6 thioalkyl, amido, (lower alkyl)amido, C6 or C10 aryl, or C7-10 aralkyl; R2 is CH2-R20, NH-R20, O-R29, or S-R20, wherein R2 is a saturated or unsaturated C3-7 cycloalkyl or C4-10(alkylcycloalkyl), all of which being optionally mono-, di- or tri- substituted with R21, or R29 is a C5 or C10 aryl or C7-14 aralkyl optionally substituted, or R20 is Het or (lower alkyl)-Het, both optionally substituted, Het or (lower alkyl)-Het; carboxyl; carboxy(lower alkyl); C6 or C10 aryl, C7-14 aralkyl or Het, said aryl, aralkyl or Het being optionally substituted; and R1 is H; C1-5 alkyl, C3-7 cycloalkyl. C2-6 alkenyl, or C2-6 alkynyl, all optionally substituted with halogen; or a pharmaceutically acceptable salt or ester thereof.

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