Hepatitis c virus asialoglycoproteins

Details Hepatitis c virus asialoglycoproteins Hepatitis c virus asialoglycoproteins

C - Chemistry, Metallurgy

07

K

C07K 14/18 (2006.01) A61K 39/29 (2006.01) A61P 31/14 (2006.01) A61P 37/04 (2006.01) C07K 1/22 (2006.01) C12N 15/51 (2006.01) C12P 21/02 (2006.01) G01N 33/564 (2006.01) G01N 33/576 (2006.01) C12N 15/85 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2095521

Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the E1 and E2 proteins aggregate in-to virus-like particles. Cells bearing a mannose receptor or asialoglycoprotein receptor are capable of being infected with HCV, and supporting culturing of the virus.

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