Hepatitis c virus asialoglycoproteins

Details Hepatitis c virus asialoglycoproteins Hepatitis c virus asialoglycoproteins

C - Chemistry, Metallurgy

12

N

C12N 15/51 (2006.01) A61K 39/29 (2006.01) C07K 1/22 (2006.01) C07K 14/18 (2006.01) G01N 33/576 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2190265

Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation in blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the E1 and E2 proteins aggregate into virus-like particles.

Deux protéines d'enveloppe du virus de l'hépatite C (E1 et E2) sont exprimées sans sialylation. L'expression par recombinaison de ces protéines dans des eucaryotes inférieurs, ou dans des cellules mammaliennes dans lesquelles la glycosylation terminale est bloquée, permet de produire des protéines recombinées qui ressemblent plus aux glycoprotéines natives du VHC. Lorsqu'elles sont isolées par affinité avec la lectine d'agglutinine galanthus nivalus, les protéines E1 et E2 s'agrègent pour former des particules ressemblant à un virus.

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