C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/02 (2006.01) C12N 9/00 (2006.01) C12N 15/86 (2006.01) C12Q 1/34 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/576 (2006.01)
Patent
CA 2481171
The present invention features assays employing a beta-lactamase reporter system, an HCV replicon enhanced cell, and/or a chimeric HCV replicon containing a 3' UTR based on the HCV-1a 3' UTR. These features can be employed alone or together, and are preferably combined together to measure HCV replicon activity and the affect of compounds on such activity
La présente invention a trait à des dosages mettant en oeuvre un système rapporteur à base de bêta-lactamase, une cellule enrichie de réplicon de l'hépatite C, et/ou un réplicon chimérique de l'hépatite C contenant un 3' UTR à base du 3' UTR de l'hépatite C-1a. Ces éléments peuvent être utilisés seuls ou en combinaison et sont de préférence combinés pour la mesure de l'activité de réplicon de l'hépatite C et l'effet des composés sur une telle activité.
Flores Osvaldo A.
Grobler Jay
Murray Edward M.
Zuck Paul D.
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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