Hepatitis c virus epitopes

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/51 (2006.01) A61K 39/29 (2006.01) C07K 14/18 (2006.01) G01N 33/576 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2079912

Peptide antigens which are immunoreactive with sera from individuals infected with hepatitis C virus (HCV) are disclosed. Several of the antigens are immunologically reactive with antibodies present in individuals identified as having chronic and acute HCV infection. The antigens are useful in diagnostic methods for detecting HCV infection in humans. Also disclosed are corresponding genomic-fragment clones containing polynucleotides encoding the open reading frame sequences for the antigenic peptides.

AntigSnes peptidiques immunor'actifs avec les s'rums provenant des personnes infect'es par le virus de l'h'patite C (HCV). Plusieurs parmi lesdits antigSnes r'agissent immunologiquement avec les anticorps pr'sents dans les personnes qui ont une infection HCV chronique ou aigu%. Les antigSnes sont utiles aux proc'd's diagnostiques de d'tection de l'infection HCV chez l'homme. On d'crit 'galement des clones de fragments g'nomiques correspondants renfermant des polynucl'otides codant les s'quences de cadre de lecture ouvert pour les peptides antig'niques.

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