Hepatitis c virus inhibitors

Details Hepatitis c virus inhibitors Hepatitis c virus inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/395 (2006.01) A61K 31/4184 (2006.01) A61K 31/437 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2753382

The present invention discloses compounds or pharmaceutically acceptable salts, esters, or prodrugs thereof, which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

La présente invention concerne des composés ou des sels pharmaceutiquement acceptables, des esters, ou des promédicaments de ceux-ci, qui inhibent des virus contenant de l'ARN, en particulier le virus de l'hépatite C (VHC). Par conséquent, les composés de la présente invention interfèrent avec le cycle de vie du virus de l'hépatite C et sont également utiles en tant qu'agents antiviraux. La présente invention concerne en outre des compositions pharmaceutiques comprenant les composés mentionnés ci-dessus pour administration à un sujet souffrant d'une infection par le VHC. L'invention concerne en outre des procédés de traitement d'une infection par le VHC chez un sujet par administration d'une composition pharmaceutique comprenant les composés de la présente invention.

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