Hepatitis c virus replication inhibitors

Details Hepatitis c virus replication inhibitors Hepatitis c virus replication inhibitors

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01) A61K 31/711 (2006.01) A61K 38/16 (2006.01) A61K 38/55 (2006.01) C07H 21/04 (2006.01) C07K 14/18 (2006.01) G01N 33/576 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2383411

The present application identifies the NS4A binding site present on NS2/3 as a target site for inhibiting NS2/3 protease activity. Methods inhibiting NS2/3 activity by targeting the identified target site are described along with examples of compounds useful in such methods and guidance for obtaining additional useful compounds. Such compounds and methods are preferably employed to inhibit HCV replication.

La présente invention concerne le site de liaison de NS4A présent sur NS2/3 en tant que site cible pour inhiber l'activité protéase NS2/3. Elle concerne également des procédés permettant d'inhiber l'activité NS2/3 par ciblage du site cible identifié, ainsi que des exemples de composés utiles dans ces procédés, et une marche à suivre pour obtenir des composés utiles supplémentaires. Ces composés et procédés sont de préférence utilisés pour inhiber la réplication du virus de l'hépatite C.

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