Hepatitis c virus replication system

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/10 (2006.01) A61K 39/29 (2006.01) C07K 14/18 (2006.01) C12N 7/00 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2581554

A cell including: (a) a hepatitis C virus genome, and/or nucleic acid encoding a hepatitis C virus genome; and (b) nucleic acid encoding one or both of hepatitis C virus proteins El and E2. The cells can be grown in culture in order to support HCV replication, and HCV virions can be purified from them.

La présente invention concerne une cellule comprenant (a) un génome du virus de l'hépatite C et/ou de l'acide nucléique codant un génome du virus de l'hépatite C et (b) de l'acide nucléique codant la protéine E1 du virus de l'hépatite C et/ou la protéine E2 du virus de l'hépatite C. Les cellules selon cette invention peuvent être mises en culture afin de permettre une réplication du VHC et des virions du VHC peuvent être purifiés à partir de celles-ci.

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