C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/40 (2006.01) C07K 14/18 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 15/51 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2434845
The present invention features nucleic acid containing one or more adaptive mutations, and HCV replicon enhanced cells. Adaptive mutations are mutations that enhance HCV replicon activity. HCV replicon enhanced cells are cells having an increased ability to maintain an HCV replicon.
La présente invention concerne, d'une part un acide nucléique comportant au moins une mutation adaptative, et d'autre part des cellules renforcées pour des réplicons du virus de l'hépatite C. Les mutations adaptatives considérées sont celles qui renforcent l'activité des réplicons du virus de l'hépatite C. Les cellules renforcées pour les réplicons du virus de l'hépatite C sont ces cellules présentant une aptitude accrue à entretenir un réplicon du virus de l'hépatite C.
de Francesco Raffaele
Migliaccio Giovanni
Paonessa Giacomo
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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