Hepatitis delta and diagnostics and vaccines

Details Hepatitis delta and diagnostics and vaccines Hepatitis delta and diagnostics and vaccines

C - Chemistry, Metallurgy

12

N

167/130, 167/140

C12N 15/51 (2006.01) A61K 39/29 (2006.01) A61K 39/42 (2006.01) C07K 14/08 (2006.01) C07K 16/10 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 9/02 (2006.01) C12N 15/53 (2006.01) C12N 15/62 (2006.01) C12Q 1/70 (2006.01) G01N 33/576 (2006.01) G01N 33/577 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1338800

The entire genome of the hepatitis D virus has been shown to be a circular single-stranded RNA of 1679 bases. Several open reading frames in both the genomic and complementary strands indicate possible protein products The products encoded in one open reading frame, ORF5, are identified as viral polypeptides p24? and p27?, of which the nuclear ? antigens in HDV infected liver is comprised. These products, as well as others encoded in ORFs 1, 2, 6, and 7 are produced in recombinant expression systems. The ORF5 products. in particular, are useful for HDV diagnosis and vaccines.

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