Hepatocellular carcinoma

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01)

Patent

CA 2760814

Present invention concerns a kit and an in vitro method, for evaluating a biological stage of an HCC tumour in an individual, based on a sample from the individual, comprising: deriving from the sample a profile data set, the profile data set on a the gene expression panel with the markers CCNG2, EGLN3, EROlL, FGF21, MATlA, RCLl and WDR45L or a substantially similar marker, being a quantitative measure of the amount of a distinct RNA or protein constituent in the panel so that measurement of the constituents enables evaluation of the biological condition or the biological behaviour HCC tumours.

La présente invention porte sur un coffret et sur un procédé in vitro, pour évaluer un stade biologique d'une tumeur d'un carcinome hépatocellulaire (HCC) chez un individu, sur la base d'un échantillon provenant de l'individu, comprenant : la déduction à partir de l'échantillon d'un ensemble de données de profil, l'ensemble de données de profil sur le panel d'expression génique avec les marqueurs CCNG2, EGLN3, EROlL, FGF21, MATlA, RCLl et WDR45L ou un marqueur sensiblement similaire, étant une mesure quantitative de la quantité d'un constituant ARN ou protéine distinct dans le panel de telle sorte que la mesure des constituants permet l'évaluation de l'état biologique ou du comportement biologique de tumeurs de HCC.

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