Hepatocellular carcinoma specific promoter and uses thereof

Details Hepatocellular carcinoma specific promoter and uses thereof Hepatocellular carcinoma specific promoter and uses thereof

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2540023

Liver cancer, particularly hepatocellular carcinoma specific promoter sequences and adenovirus vehicles are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication will be restricted to the target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity, for treating neoplasia.

L'invention se rapporte au cancer du foie, et plus particulièrement de séquences de promoteurs spécifiques du carcinome hépatocellulaire, ainsi que de véhicules adénoviraux. Etant donné que la régulation du lancement de la transcription est liée à des facteurs de transcription qui ne sont actifs que dans des types de cellules spécifiques et limités, la réplication virale se limite systématiquement aux cellules cibles. L'adénovirus modifié convient comme véhicule servant à introduire de nouvelles aptitudes génétiques, notamment celle associées à la cytotoxicité, pour traiter la néoplasie.

Affiliated with

Also associated with

Rating

Hepatocellular carcinoma specific promoter and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hepatocellular carcinoma specific promoter and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hepatocellular carcinoma specific promoter and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1787534