Hepatocyte growth factor

Details Hepatocyte growth factor Hepatocyte growth factor

C - Chemistry, Metallurgy

07

K

167/103.45

C07K 14/475 (2006.01) A61K 35/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1300010

- 17 - ABSTRACT: A hepatocyte growth factor comprising a proteinous substance derived from human blood and showing the following physicochemical properties and physiologic activity: i) its molecular weight is estimated to be approximately 76,000 to 92,000 by SDS-PAGE analysis (under non-reductive condition); ii) it possesses HGF activity; iii) the HGF activity is inactivated by heat treatment for 10 minutes at 80°C; iv) the HGF activity may be lost by digestion with trypsin or with chymotrypsin; and v) it has a high affinity for heparin.

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